All about Xanax
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Benadryl vs XanaxThe dangers of mixing Benadryl and Xanax were discussed long ago. But the fact remains: most users don’t mind them. Benadryl is a known prescription chemical that treats itching and allergic reactions, swelling and rash, hives and even insomnia. Is it effective? Definitely! Can it be dangerous? Yes it can be, when mixed with other meds, abused and taken in doses higher than prescribed.

Can you mix Xanan with Benadryl? Xanax (or Alprazolam) is recommended for anxiety and depression treatment. It also copes with panic attacks and withdrawal symptoms. Xanax and Benadryl are two different kinds of medications. The first one is benzodiazepine and the second one is an antihistamine. Being different in nature, they lead to very dangerous health issues, if taken at the same time.

How to Use Xanax or Benadryl?

Xanax (or Alprazolam) is generally prescribed to treat mental health disorders in patients above 18. Its use in children hasn’t been properly studied yet, which is why it is never prescribed to those less than 18 years old.

It has proven its efficacy in the treatment of panic disorders, anxiety, stress and depression, insomnia, seizures, withdrawal from alcohol. There are some other non-prescription uses. They should be discussed with a healthcare professional. In case you suffer from kidney/liver condition, have heart disease or its history, inform your doctor to have a safe dose adjusted.

Benadryl is an over-the-counter drug. There are several conditions that this medication works for. Today their list includes:

  1. Allergic reactions;
  2. Hives;
  3. Swelling;
  4. Rash;
  5. Insomnia.

Though it is regarded as a relatively safe remedy, you still need to inform your healthcare provider of the following conditions before administering Benadryl:

  • Breastfeeding;
  • Pregnancy (planning to get pregnant);
  • Unusual allergic reactions to other drugs, foods, drinks and preservatives;
  • Measles;
  • Chicken pox.

Xanax vs. Benadryl: What Side Effects Do They Cause?

If taken according to prescription or label instructions, both meds are safe. However, they can also trigger adverse body reactions, if prescription recommendations are neglected.

Benadryl may be responsible for:

  • Serious allergic reactions, face swelling, hives and itching;
  • Dry mouth/nose/throat and headaches;
  • Dizziness and drowsiness;
  • Tiredness and sedations;
  • Poor coordination and sleepiness;
  • Difficulty urinating and upset stomach.

There are also patients, who report vision problems (blurred and/or double vision). Some face the decrease of appetite.

When Benadryl compared to Xanax, the side effects of the latter one are more serious, as a rule (however, cases may differ). When you take Alprazolam in doses that are higher than you need, you will experience:

  • Poor coordination as well as balance problems;
  • Insomnia and loss of memory (temporary);
  • Dizziness and hangover effects;
  • Problems concentrating and slurred speech.

Some users also report diarrhea (either mild or severe), nausea and/or vomiting, migraines and severe sweating, appetite changes, etc.

If both meds leads to such complications, can you take Xanax with Benadryl at the same time?

Xanax vs. Benadryl: Drug Interaction

Though there’s a great difference between Xanax and Benadryl, they have many common side effects. Benadryl is known for interacting with some other drugs. They can either reduce or enhance the pharmacological effects of the medication. Some of them add to the severity of adverse reactions, too.

Taking Xanax with Benadryl is not just NOT recommended, it’s forbidden. The outcome can be fatal. The thing is that these remedies are sedating, which means that they can increase each other’s effects and turn them into negative ones. The interaction of this kind is called a life-threatening one. Is Benadryl like Xanax? When it comes to adverse reactions, they are very much alike. Their simultaneous administration leads to:

  1. Dizziness;
  2. Drowsiness;
  3. Confusion;
  4. Breathing problems;
  5. Insomnia;
  6. Loss of coordination;
  7. Coma;
  8. Death.

The relation Alprazolam vs. Diphenhydramine has never been regarded as a safe one. Health and life complications are everything it can lead to. When you take these medications, be sure they are administered only as prescribed. Besides, operating a car or heavy machinery under the effect of Xanax vs. Diphenhydramine is forbidden. Unless you’re not afraid to fall asleep or lose consciousness, while at the wheel.

Dr. Andrew J. Olson

Author: Dr. Andrew J. Olson

Dr. Andrew J. Olson is a PHD in psychiatry. He is also a psychiatrist consultant at the Royal Berkshire NHS Foundation Trust. He also serves as a Clinical Director of the Department of Psychiatry, at Royal Marsden Hospital, in London, UK.


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The dangers of mixing Benadryl and Xanax were discussed long ago. But the fact remains: most users don’t mind them. Benadryl is a known prescription chemical that treats itching and allergic reactions, swelling and rash, hives and even insomnia. Is it effective? Definitely! Can it be dangerous? Yes it can be, when mixed with other meds, abused and taken in doses higher than prescribed. Can you mix Xanan with Benadryl? Xanax (or Alprazolam) is recommended for anxiety and depression treatment. It also copes with panic attacks and withdrawal symptoms. Xanax and Benadryl are two different kinds of medications. The first…
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