All about Xanax
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Codeine and XanaxEvery person undergoes a lot of pressure and events during lifetime. Our bodies are much more vulnerable than we would want them to be. The worldwide statistics shows that every second person you meet is suffering from more than two diseases.

No matter how you got the disease, whether it is inborn or acquired, it should be treated well. Modern medications allow curing nearly everything. Since most people have more than two illnesses, the question of the possibility of drug combinations is always of current importance.

This time we are going to give an overview of two extremely popular medications, like Xanax and Codeine. Having read this article, you will be familiarised with the effect of each drug and know the answer to the most worrying question: can you take Xanax with Codeine or not?

Is Codeine like Xanax? How they stack up

The first thing you should know about these two drugs is that their designation is completely distinct. The main difference between Xanax and Codeine is in the active components, Alprazolam (for Xanax) and Codeine.

Alprazolam vs Codeine

Being a benzodiazepine, Alprazolam has an impact on the unbalanced brain chemicals. This helps to treat the following nervous system dysfunctions:

Alprazolam is under the restriction in most countries of the world and, as a result, can be purchased with prescription only.

Codeine belongs to opiates and is mostly applied as a pain reliever. Apart from that, Codeine is used in the following cases:

  • Cough
  • Diarrhoea
  • Irritable bowel syndrome

Some doctors prescribe Codeine to relieve the cancer pain, but the drug’s effectiveness for this purpose is a heated debate. Codeine compared to Xanax is much more difficult to get, especially without a prescription. This substance is also illegal in a number of countries.

Codeine vs Xanax: Forms and Dosing

The original Xanax is produced by a well-known Pfizer company. Codeine is presented in various forms and is usually sold as a mixture with other components. The Codeine Sulphate pills and oral solutions are manufactured by Roxane Laboratories Incorporation.

Tablet forms

To make the drug identification easier, Xanax is distributed in tablets of various colours and shapes. Xanax is issues in the following strengths:

  1. White round pills of 0.25 mg
  2. Orange and elliptical – 0.5 mg
  3. Purple oval-shaped footballers – 1 mg
  4. White and capsule-shaped – 2 mg

Except for the 0.25mg dose, all pills have special splitting divisions for simplifying the process of dosing.

Codeine Sulphate tablets are round-shaped white and can be identified by their imprints:

  • 54 613 – 15 mg
  • 54 783 – 30 mg
  • 54 412 – 60 mg

As it was mentioned before, Codeine is also available as substance for oral use. Its concentration of Codeine Sulphate is 6 mg per millilitre.

Xanax: dosing

Alprazolam doses should be prescribed and adjusted by doctors. The recommended initial point for anxiety treatment comprises 0.75-1.5 mg per day, divided into 2-3 intakes. The dosage for panic disorders should be doubled.

According to the body’s response to the drug, Xanax dose should be slowly increased. However, it is highly recommended to use the smallest amount that proves to be effective. The daily limit contains 10 mg of Alprazolam.

Codeine: dosing

The codeine dose depends on the severity of pain and the degree of opioid tolerance. The initial dosage for pain relief contains 15-30mg taken every 4 hours if there is such necessity. The dose can be increased up to 60 mg, but the total amount of Codeine should not be more than 360 mg per day.

This applies for the Codeine Sulphate pills, but the dosing for oral solution can be easily calculated based on the proportion mentioned above.

Xanax vs Codeine: the cost of treatment

The cost of Xanax pills varies from $1.95 to $3.33 according to the Alprazolam strength and amount of pills in the box. The price of Codeine tablets is $0.5-$3.2 depending on the strength as well. Codeine Sulphate oral solutions are a bit more expensive than the pills.

Xanax vs Codeine: Warnings and Precautions

Do not take Xanax if you have been diagnosed with one of the following illnesses:

  • Glaucoma
  • Allergy to Alprazolam and other benzodiazepines
  • Severe depression
  • Suicidal attempts records
  • Asthma or other breathing problems
  • Severe heart, liver or kidney condition

Codeine should not be prescribed in the following cases:

  1. Allergy to Codeine or other opiates
  2. Paralytic ileus (bowel obstruction)
  3. Asthma attacks
  4. Hyperventilation

Using Xanax or Codeine during pregnancy and breastfeeding should be avoided due to the possible life-threatening conditions. These medications are quite strong, so they are contraindicated to children.

Side Effects

Usually patients who take Xanax experience the feeling of light-headedness, dizziness, high irritability and problems with concentration or coordination. The occurrence of these reactions should not bother during the first 8-10 days of treatment.

Adverse reactions to Codeine include fever, fainting, nausea, being too relaxed and calm. Any unusual symptoms have to be reported to the doctor at the short notice.

Addiction and Overdose

Being an opium, Codeine can cause addiction and, as a result, overdose. The overdose with this drug is extremely dangerous and required immediate medical help. The symptoms are changes or complete loss of consciousness, chest pain, bluish lips, absence of blood pressure and pulse.

Xanax overdose can be recognized if the person faints, has troubles with coordination, confused, and feels extreme weakness in the muscles. As well as Codeine, Xanax overdose can be fatal.

Can you mix Xanax and Codeine?

Since both medications are causing quite similar side effects, mixing Codeine and Xanax can make the adverse reactions more severe and dangerous. Overdosing with these drugs increases the risk of fatal outcome greatly. Visit your healthcare provider and talk about the possibility of taking Xanax with Codeine.

Dr. Andrew J. Olson

Author: Dr. Andrew J. Olson

Dr. Andrew J. Olson is a PHD in psychiatry. He is also a psychiatrist consultant at the Royal Berkshire NHS Foundation Trust. He also serves as a Clinical Director of the Department of Psychiatry, at Royal Marsden Hospital, in London, UK.


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Every person undergoes a lot of pressure and events during lifetime. Our bodies are much more vulnerable than we would want them to be. The worldwide statistics shows that every second person you meet is suffering from more than two diseases. No matter how you got the disease, whether it is inborn or acquired, it should be treated well. Modern medications allow curing nearly everything. Since most people have more than two illnesses, the question of the possibility of drug combinations is always of current importance. This time we are going to give an overview of two extremely popular medications,…
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