All about Xanax
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Flexeril and XanaxThe modern lifestyle might be quite stressful for many individuals. Routine stress can lead to severe consequences and increase tension. There is no wonder that nowadays more and more people are seeking for a professional medical help.

Luckily, the pharmaceutical industry has presented a plenty of solutions to this problem. The variety of antidepressants and medications with relaxing effect is amusing. But as a result, many people get confused with the choice.

For example, the frequent confusion occurs with the questions like, can you mix Xanax and Flexeril? If not, you are probably wondering which one is the best for you. This article will help you make up your mind.

Xanax vs. Flexeril: how they stack up

Xanax belongs to the list of the most frequently prescribed drugs in the world. The numerous studies and laboratorial experiments prove its effectiveness. Just like Xanax, Flexeril is considered to be one of the best drugs in the category, but it is less popular. Is Flexeril like Xanax in terms of its quality and efficacy?

Alprazolam vs. Cyclobenzaprine

Alprazolam and Cyclobenzaprine are the active components of Xanax and Flexeril correspondently. Alprazolam is widely used to cure anxiety and its symptoms, panic attacks and social anxiety. The least traditional applications are as follows:

  • menstrual pain
  • intense stress
  • depression
  • muscle tremors

Cyclobenzaprine is generally applied in the following cases:

  • muscle spasms
  • acute pain
  • severe musculoskeletal condition
  • supplement to the physical therapy

The difference between Xanax and Flexeril is that Alprazolam has a direct impact on the nervous system, while Cyclobenzaprine only works as a barrier of the nerve impulses. The table below represents the comparison of drug’s components, based on six criteria.

Characteristics Alprazolam Cyclobenzaprine
Trade names Xanax Amrix (former Flexeril)
Legal status POM (UK) Schedule IV (US) ℞ (Prescription only)
Metabolism Hepatic, via Cytochrome P450 3A4 hepatic
Excretion Renal renal
Bioavailability 80–90% 33% to 55%
Formula C17H13ClN4 C20H21N

 

Flexeril vs. Xanax: Forms and Dosing

Flexeril is produced by Merck & Co. Inc and it is issued in five-sided pills of two strengths:

  • 5 mg – orange, with FLEXERILL imprint on one side
  • 10 mg – yellow, marked with FLEXERILL on one side and MSD 931 on the other

The 5 mg pills are packed in blisters of 6, while 10 mg tablets are available in boxes of 100 items.

Xanax is manufactured by Pfizer and has a wider range of forms that include the following:

  • 0.25 mg – white oval, labelled Xanax 0.25 on one side
  • 0.5 mg – orange elliptical, marked Xanax 0.5, has 1 splitting division
  • 1 mgpurple oval, Xanax 1 imprint, 1 splitting division
  • 2 mg – white capsule-shaped, Xanax 2 marking, 3 divisions

Dosing information

Xanax has to be taken with extreme caution. The strict prescription maintenance is of a great importance. The initial dose should contain 0.25-0.5 mg of Alprazolam taken three times a day. During the treatment the dose is to be increased slightly due to the patient’s needs. The upper limit amount of Alprazolam is 10 mg per day.

Like Xanax, Flexeril has to be applied three times a day. The recommended start point is 5 mg that might be increased up to 10 mg according to the patient’s response to the drug.

Elderly people have to take smaller amounts of these medications due to the aging process and possible side effects.

Xanax vs. Cyclobenzaprine: what they cost

Flexeril compared to Xanax is much more difficult to get. The average price for one 10 mg Flexeril pill slightly exceeds $2. Xanax, on the other hand, is available almost in any drug store and the price per one 2 mg tablet varies from $2.3 to $3.3.

The regional aspect plays a huge role in determining the cost of the medicine due to the shipping expenditures.

Side Effects

The adverse reactions to Xanax usually occur during the first during the first week of treatment. The following reactions should not bother the patient much:

  1. drowsiness
  2. weight loss
  3. increased irritability
  4. ataxia
  5. headaches
  6. increased or decreased appetite

The side effects to Flexeril include drowsiness, xerostomia and fatigue. The more severe ones comprise changes in face colour, irregular breathing and hives.

Allergic reactions and overdose

The allergic reaction to Alprazolam and Cyclobenzaprine are similar and are displayed by itching, face swelling. The overdose symptoms are alike as well and include the following signs:

  1. dizziness
  2. convulsions
  3. severe drowsiness
  4. troubles with breathing
  5. vomiting

Physical and psychological addiction

Both Xanax and Flexeril are habit forming, which might cause addiction. It makes the drug withdrawal a hard and painful process. Patients suffering from addiction to Alprazolam and Cyclobenzaprine experience the general impairment of the health condition.  The misuse of such medications might also lead to overdose or death.

Warnings and Precautions

Avoid doing activities that require a lot of concentration while treating with Xanax or Flexeril. These medications slow down the reactions, as a result taking Xanax with Flexeril will cause problems with coordination and thinking process.

Do not take Flexeril, if you have experienced heart attacks, heart block, overactive thyroid or heart rhythm disorder recently. You should not take Flexeril, if you have recently had a heart attack, or if you have a heart rhythm disorder, congestive heart failure, heart block, or an overactive thyroid.

Xanax is contraindicated for patients with glaucoma. It is also dangerous for people with suicidal thoughts and severe depression. The occurring side effects might lead to deterioration of that condition.

Pregnancy and breastfeeding

As to the pregnancy threat, Flexeril belongs to the category B, while Xanax has been qualified as a highly dangerous and has got the category D. Flexeril can be applied by pregnant women, but they should take into account the fact that its influence has not been fully investigated.

Alprazolam penetrates into breast milk, that is why Xanax is not recommended for breastfeeding women. The excretion properties of Cyclobenzaprine remain unknown.

Mixing Flexeril and Xanax

Mixing Flexeril and Xanax is not contraindicated, but extreme cautiousness should be maintained. The simultaneous application of Alprazolam and Cyclobenzaprine might cause the increase the probability of experiencing side effects.

Can you take Xanax with Flexeril and stay productive? It depends on the individual, but in most cases, the combination of these medications causes problems with concentration and extreme tiredness.

Dr. Andrew J. Olson

Author: Dr. Andrew J. Olson

Dr. Andrew J. Olson is a PHD in psychiatry. He is also a psychiatrist consultant at the Royal Berkshire NHS Foundation Trust. He also serves as a Clinical Director of the Department of Psychiatry, at Royal Marsden Hospital, in London, UK.


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The modern lifestyle might be quite stressful for many individuals. Routine stress can lead to severe consequences and increase tension. There is no wonder that nowadays more and more people are seeking for a professional medical help. Luckily, the pharmaceutical industry has presented a plenty of solutions to this problem. The variety of antidepressants and medications with relaxing effect is amusing. But as a result, many people get confused with the choice. For example, the frequent confusion occurs with the questions like, can you mix Xanax and Flexeril? If not, you are probably wondering which one is the best for…
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