All about Xanax
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Buspirone like xanaxAnxiety is one of the most common nervous system dysfunctions not only in the United States, but also in Australia and in a number of European and Asian countries. Anxiety affects the human life greatly and prevents from being physically and socially active.

Xanax and Buspirone are great choices for anxiety treatment. It is approved by numerous studies and experiments. Although not many people have heard of Buspirone, as Xanax has received most of the popularity and customer approval. Are these drugs similar or completely different? Can you take Xanax with Buspirone? To find it out, it is important to understand how each of these medications works.

Buspirone vs. Xanax: is there any difference?

Firstly, both Xanax and Buspirone are anxiolytic drugs, which means that they can decrease anxiety levels. The difference between Xanax and Buspirone is that they belong to different classes. Alprazolam, which stands for Xanax, is a benzodiazepine while Buspirone is an azapirone.

Xanax and Buspirone are used for treating the following nervous system diseases:

Many people also apply these medicines to relieve the pain and deal with symptoms of PMS.

Alprazolam vs. Buspirone

As it can be observed from the table below, Xanax is more popular than Buspirone. Another major difference between Xanax and Buspiron is that the later has an extremely small half-life of 2ß3 hours while Alprazolam can stay in the body up to 16 hours.

Substance Alprazolam Buspirone
Current rating 3.13/5 0/5
Trade names Xanax Buspar
Half-life Immediate release: 11.2 hours; Extended release: 10.7–15.8 hours 2-3 hours
Bioavailability 80–90% 5%
Excretion Renal Urine (29-63%), Feces (18-38%)
Metabolism Hepatic, via Cytochrome P450 3A4 Hepatic
Formula C17H13ClN4 C21H31N5O2

Furthermore, these drugs have different ways of excretion. Alprazolam has a nephritic way and Buspirone is mostly coming out with urine.

Xanax vs. Buspirone: forms

Xanax can be found in various strengths, which makes it extremely comfortable to apply. Furthermore, pills with big amounts of Alprazolam have splitting divisions that allows to perform a very accurate dosing.  You can find both original and generic versions on the pharmaceutical market.

Xanax, manufactured by Pfizer US Incorporation, has the following variations:

Just like Xanax, Buspirone is available in a huge number of versions from different manufacturers. You can come across Buspar, which is a brand name for Buspirone. There are also Buspirone hydrochloride pills, produced by the famous Mylan Pharmaceuticals Incorporation.

Buspirone hydrochloride tablets are issued in the following strengths:

  • 5 mg
  • 10 mg
  • 15 mg

These pills also have divisions for splitting and imprints with the dose to make it more recognizable among other drugs.

Xanax and Buspirone: dosing

The dosing principle for treating anxiety with Xanax and Buspirone is quite similar. Both medications should be applied three times a day at equal dosages. The initial dose for Xanax is 0.25-05mg per intake and for Buspirone it is 5 mg.

You should increase the dosage every three-four days according to your body’s reactions. The raising steps are 0.5 mg and 5 mg for Xanax and Buspirone correspondingly. The maximum dose for Xanax is 6 mg per day, for Buspirone it is 60 mg.

Xanax and Buspirone should be taken before or after the food consumption with a sufficient amount of water. Do not crash the tablets or take any of these pills with alcohol.

Xanax vs. Buspirone: precautions and contraindications

Under no circumstances you should apply Xanax, if you experience one of the following:

  1. allergy to benzodiazepines
  2. breathing problems
  3. narrow angle glaucoma
  4. suicidal thoughts
  5. kidney or liver diseases

Buspirone is contraindicated in the situations listed below:

  1. Buspirone hypertensity
  2. diabetes
  3. treating with MAO inhibitors
  4. liver or renal function abnormality

Pregnancy and breastfeeding

Xanax should not be taken by pregnant women due to the hazard to the mother and foetus. Alprazolam also causes difficulties with birth. Unlike Xanax, Buspirone is safe for pregnant women, as it does not cause any threat to the baby.

It is recommended not to breastfeed during the treatment with Xanax or Buspirone. Studies suggest that these substances penetrate into breast milk, which might cause bad effect on the child.

Dependence and drug withdrawal

Alprazolam is a habit-forming drug and if it is misused, it might cause psychological and physical addiction. Do not stop taking Xanax suddenly as the drug withdrawal will be hard. For this reason, this process should be slow and gradual.

The significant difference between Buspirone and Alprazolam is that the former does not form any kind of addiction, as it is more secure to take.

Side effects

Xanax usually causes the following reactions during the first few weeks of treatment:

  • drowsiness
  • tiredness
  • slight hallucinations
  • dizziness
  • nausea
  • ataxia

Buspirone causes the following side effects:

  • headache
  • chest pain
  • dizziness
  • nervousness
  • feeling of confusion
  • muscle weakness

In case you notice one of the reactions, mentioned above, you should call for the medical help.

Can you mix Xanax and Buspirone?

In case you are concerned about mixing Buspirone and Xanax, you have to calm down as there is nothing to worry about. These two medications do not have any dangerous interactions, but as they have the same effect, mixing Buspirone and Xanax would increase the sedative and anticonvulsant properties. To make sure it is safe for you, talk to your doctor about the security of mixing Buspirone and Xanax.

Xanax or Buspirone: the cost of treatment

The pricing policies for Xanax and Buspirone are quite different. The box of 360 1 mg Xanax pills costs approximately $700, which is $1.95 per pill. The same box of 10 mg Buspar tablets costs on average $126.45 ($0.35 for tablet).

Dr. Andrew J. Olson

Author: Dr. Andrew J. Olson

Dr. Andrew J. Olson is a PHD in psychiatry. He is also a psychiatrist consultant at the Royal Berkshire NHS Foundation Trust. He also serves as a Clinical Director of the Department of Psychiatry, at Royal Marsden Hospital, in London, UK.


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Anxiety is one of the most common nervous system dysfunctions not only in the United States, but also in Australia and in a number of European and Asian countries. Anxiety affects the human life greatly and prevents from being physically and socially active. Xanax and Buspirone are great choices for anxiety treatment. It is approved by numerous studies and experiments. Although not many people have heard of Buspirone, as Xanax has received most of the popularity and customer approval. Are these drugs similar or completely different? Can you take Xanax with Buspirone? To find it out, it is important to…
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