All about Xanax
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Seroque and XanaxIf you are suffering from nervous system disorders, you have probably been prescribed with a lot of different drugs. Some of them might not be right for you and need to be substituted. Or maybe you have experienced such diseases in the past and try to catch on with modern medicine.

It is hard for a modern person to find time for numerous visits to the hospitals. As a result, many people are seeking for information online and try to understand what suits best to them. This article gives the overview of two popular medications, Xanax and Seroquel.

You will find answers to the most frequently asked questions, for instance, Can you take Xanax with Seroquel? What should I consider before taking these drugs? What is the difference between Xanax and Seroquel?

Is Seroquel like Xanax? How they stack up

Seroquel and Xanax are quite different regarding their action on the body. Quetiapine that contains in Seroquel is an antipsychotic drug, which is aimed to change the chemical reactions in the brain.

The Xanax active component, Alprazolam, has a sedative, anxiolytic, muscle relaxant and anticonvulsant effect. Alprazolam adjusts and normalizes the functions of nervous system.

Alprazolam vs. Quetiapine: indications

Alprazolam is prescribed to treat the following central nervous system illnesses:

  • panic and anxiety disorder
  • insomnia
  • nausea caused by chemotherapy
  • severe depressive condition

The off-label application of Xanax is to relieve the pain before and during the menstrual cycle. Sometimes Xanax is prescribed as an addition to the alcohol dependence treatment.

Quetiapine is designated to cure the following diseases:

  1. schizophrenia
  2. manic depression (also known as bipolar disorder)
  3. major depressive disorder

Other and not widely approved applications include treating Tourette syndrome, anxiety, depression, musical hallucinations, Parkinson’s disease psychosis.

Component Alprazolam Quetiapine
Current rating 3.13/5 0/5
Trade names Xanax Seroquel
Legal status POM (UK) Schedule IV (US) AU: Prescription Only (S4), UK: POM, US: ℞-only
Bioavailability 80–90% 100%
Excretion Renal Renal (73%), faeces (20%)
Metabolism Hepatic, via Cytochrome P450 3A4 Hepatic via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)
CAS number 28981-97-7 111974-69-7
Formula C17H13ClN4 C21H25N3O2S
Bioavailability 80–90% 100%

The table above describes the main biological features of Alprazolam and Quetiapine as well as provides additional information, valuable for consumers.

Seroquel vs. Xanax: Drug Forms and Dosing

Seroquel is produced by AstraZeneca Pharmaceuticals, while Xanax is manufactured by Pfizer U.S. Pharmaceuticals Group. There are many generic versions of these drugs and their origin and can be identified by the National Identity Code.

Tablet forms

Seroquel pills can be found in the following strengths:

  • 25 mg
  • 50 mg
  • 100 mg
  • 200 mg
  • 300 mg
  • 400 mg

Tablets with 300mg and 400 mg of Quetiapine are capsule-shaped, while all other pills are round. The Seroquel pills are very comfortable for dosing and consuming, as all of them have the imprint stating the amount of Quetiapine.

Original Xanax is available in four different strengths, while generics are more diverse. The Xanax strengths are as follows:

  • 25 mg
  • 5 mg
  • 1 mg
  • 2 mg

There are also 0.75 mg and 3 mg generic pills including the Xanax extended-release tablets.

Dosing Xanax or Seroquel

Xanax is should be administered three times a day in equal amounts. The recommended initial dose varies from 0.25 mg to 0.5 mg depending on the disease. Every three-four days the dosage should be increased. The maximum allowed amount of Alprazolam is 6 mg for patients with anxiety and 10 mg for severe depression treatment. Xanax can be taken both with or without food with a sufficient amount of water.

Seroquel compared to Xanax has a more sophisticated dosing system. The amount of Quetiapine depends on the illness and patient’s age. Generally, the doses for teenagers aged from 13 to 17 have to be increased more slowly than for adults. For example, the recommended dosing for schizophrenia treatment is:

  • First day: 50 mg with an increase up to 300-400 mg per on day 3. The recommended dose: 150-550 mg per day; maximum: 750 mg
  • First day: 25 mg in two intakes. Days 2-5: +100 mg each day, distributed among 2-3 intakes. Recommended dose: 400-500 mg; limit: 800 mg

Xanax vs. Quetiapine: how much does it cost

Xanax tablets cost from $1.91 to $3.35 on average. The price depends on the strength and number of pills in the box. The price for Seroquel 50 mg tablets is $0.75-$1.5 while 300mg pills are the most expensive and might cast up to $6.13 per tablet. Mixing Seroquel and Xanax would cost over 15 dollars a day.

Xanax vs. Seroquel: Warnings and Precautions

You should avoid taking Xanax or Seroquel in the following cases:

  1. narrow-angle glaucoma
  2. allergy to benzodiazepines
  3. breathing problems
  4. high or low blood pressure
  5. heart disease
  6. seizures
  7. severe depression

Do not apply Alprazolam and Quetiapine during pregnancy and breastfeeding. According to the clinical studies, these components have a bad influence on the fetus and newborns.

Side Effects

The frequency of reporting adverse reactions to Xanax is high during the first few days of the therapy. Common complaints include:

  • nausea
  • tiredness and weakness
  • digestive problems
  • ataxia
  • memory impairment

Patients treating with Seroquel often experience the following reactions to the drug:

  • headaches
  • increased hormone levels
  • xerostomia
  • weakness
  • drowsiness
  • dizziness
  • tachycardia

If the side effects you have are very severe and last more than several days, you should report this to your doctor at short notice.

Can you mix Xanax and Seroquel?

If you are wondering about the possibility of taking Xanax with Seroquel, take into account the fact that this combination is quite risky. Mixing Seroquel and Xanax increases the possibility of having such side effects as drowsiness, confusion, problems with movement coordination and general weakness. If it is medically necessary, you should be extremely careful and avoid activities that need a lot of concentration.

Dr. Andrew J. Olson

Author: Dr. Andrew J. Olson

Dr. Andrew J. Olson is a PHD in psychiatry. He is also a psychiatrist consultant at the Royal Berkshire NHS Foundation Trust. He also serves as a Clinical Director of the Department of Psychiatry, at Royal Marsden Hospital, in London, UK.


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If you are suffering from nervous system disorders, you have probably been prescribed with a lot of different drugs. Some of them might not be right for you and need to be substituted. Or maybe you have experienced such diseases in the past and try to catch on with modern medicine. It is hard for a modern person to find time for numerous visits to the hospitals. As a result, many people are seeking for information online and try to understand what suits best to them. This article gives the overview of two popular medications, Xanax and Seroquel. You will…
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