All about Xanax
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Vicodin and XanaxDrug interaction leads to more serious health complications than treated in 87% of cases. Much is said about what can or can’t be combined. But every time it comes to Xanax vs. Vicodin issues users lack important information. We believe that it is high time to change that.

What are Xanax and Vicodin? How to Use Them Safely?

There are two irreconcilable medications. Xanax treats panic attacks and anxiety disorders that are related to stress and depression. Vicodin (Hydrocodone) is a prescription painkiller – opioid – that contains hydrocodone and acetaminophen. The latter one is responsible for relieving fever and pain.

Is Vicodin like Xanax? Definitely, not! The medications are different in terms of ingredients, action method and onset. Yet they both are very potent and that’s their advantage and drawback. No matter what you might have been said, there are ways to use both drugs in a safe manner. For example, in the case you are recommended and prescribed Vicodin, you should take exactly as it’s said in the recipe. Administration of higher doses leads to overdose. Serious health issues always go along.

Xanax vs. Hydrocodone: Do They Interact?

There is a number of medications that can interact with Vicodin. When used alone, the drug can sometimes trigger tiredness or drowsiness, dizziness or reduced mental and physical function. When two potent medications are administered together, adverse reactions get severer.

Vicodin does interact with:

  • Xanax and other benzodiazepines;
  • Antipsychotics that are prescribed for depression, bipolar disorder or schizophrenia;
  • Opioids and narcotics;
  • Antihistamines that are recommended for cases of allergic reactions.

As you see, taking Xanax with Vicodin does have its effects. They both have a very high potential for addiction as well as abuse when taken separately. Not speaking of the cases, when they are taken together. Today they both are added to the list of drugs that cause overdose, coma, and even death.

Over the past years, it has been proved that there’s a huge difference between Xanax and Vicodin. Yet their combination is very dangerous. They make each other’s negative sides severer: benzodiazepines enhance the so-called high effects from Vicodin.

When a person becomes addicted to an opioid, he starts developing a tolerance with time. It means that to experience the same effect a patient needs to take a higher dose. Mixing Vicodin and Xanax leads to the same euphoric effects. However, they go hand in hand with adverse reactions.

The Xanax vs. Hydrocodone combination is called deadly and it leads to two serious problems:

  1. Enhanced sedation;
  2. Depressed breathing.

Why are these issues so dangerous? They both cause deaths unless professional medical help is provided timely.

Can You Take Xanax with Vicodin Safely?

It is usually unsafe. Even when taken in low doses, two remedies are associated with addiction in its severest form. Abusers like mixing Vicodin and Xanax to promote each other’s effects. The starting doses are 10-15 mg. They are also called moderate ones. In time, they turn into 20-30 mg doses of Vicodin – high ones. Abusers take much higher doses to ensure better euphoric and calming effects.

When prescribed properly, each drug is effective for a short-term treatment. If used when not needed (abused), both chemicals make a person suffer from severe addiction consequences. Former drug abusers should refuse from taking Xanax or Vicodin as recreational meds. The majority of them get back to addiction. Lethal outcomes aren’t rare.

1-4 mg doses of Xanax are not much for drug abusers. Addiction develops when over 20 mg is administered daily. Very often these 20 mg doses lead to irreversible overdoses and deaths. Some people administer Vicodin and Xanax bars.

So, can you mix Xanax and Vicodin? These two substances are never mixed for therapeutic purposes. Only drug abusers administer them with no intervals, putting their health and life at risk.

Is Lethal Outcome Real?

It’s very real. Much is said about Vicodin vs. Xanax interactions, yet the cases of deaths are somehow omitted. When the doses of both medications go up, they depress one’s respiratory system. Sometimes, when taken under a professional supervision in very low doses, they are relatively safe.

When Vicodin compared to Xanax, it remains in the system for 4-5 days. But first effects vanish sooner. Xanax is detected up to 5-6 weeks after the last administration. Giving the precise timeframe is hard as too many factors play a role (activity levels, metabolism rate, etc.). But taking Vicodin after Xanax administration may be not safe. Even if several days have passed.

Please, pay special attention to Xanax vs. Hydrocodone interactions. If it happened so that you can’t do without both drugs, ask your doctors to have doses adjusted in a way to remain effective and safe in both conditions.

Dr. Andrew J. Olson

Author: Dr. Andrew J. Olson

Dr. Andrew J. Olson is a PHD in psychiatry. He is also a psychiatrist consultant at the Royal Berkshire NHS Foundation Trust. He also serves as a Clinical Director of the Department of Psychiatry, at Royal Marsden Hospital, in London, UK.


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Drug interaction leads to more serious health complications than treated in 87% of cases. Much is said about what can or can’t be combined. But every time it comes to Xanax vs. Vicodin issues users lack important information. We believe that it is high time to change that. What are Xanax and Vicodin? How to Use Them Safely? There are two irreconcilable medications. Xanax treats panic attacks and anxiety disorders that are related to stress and depression. Vicodin (Hydrocodone) is a prescription painkiller – opioid – that contains hydrocodone and acetaminophen. The latter one is responsible for relieving fever and…
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