All about Xanax
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Wellbutrin + XanaxThe variety of antidepressants in the drug stores is impressing. The demand for this medicine is increasing nearly 25% every year. Depression has different stages of severity and each of them requires a special treatment.

Modern medications are extremely effective and diverse that allows choosing the best treatment for everyone. Xanax and Wellbutrin are well-known brands that can be found in every fifth prescription in the United States of America. Is Wellbutrin like Xanax? How are they different from each other? Can you take Xanax with Wellbutrin? What is the best antidepressant?

To answer these and other questions, it is important to understand how these drugs work and what they consist of.

Xanax vs. Wellbutrin: how they stack up

Wellbutrin compared to Xanax is less popular and it is produced by GlaxoSmithKline Company. The production of Xanax is managed by Pfizer, a well-known manufacturer in the whole world.

The main substance in Wellbutrin is Bupropion, which is used for curing the following illnesses:

  • depression
  • smoking cessation
  • lack of attention caused by hyperactivity
  • sexual dysfunctions (off-label use)

Alprazolam that contains in Xanax pills helps with the treatment of these nervous system dysfunctions:

  • anxiety
  • panic attacks
  • insomnia
  • nausea
  • severe stress

These substances are under governmental control in most regions of the world, that is why they can be issued only to those, who have a prescription.

Alprazolam vs. Bupropion: comparison

The following table presents the comparison between Alprazolam and Bupropion. It is shown the customers evaluation along with essential pharmaceutical properties.

Component Alprazolam Bupropion
Current rating 3.13/5 2.75/5
Trade names Xanax Wellbutrin, Zyban
Half-life Immediate release: 11.2 hours; Extended release: 10.7–15.8 hours 20 hours
Bioavailability 80–90% 5 to 20% in animals; no studies in humans
Excretion Renal Renal (87%), fecal (10%)
Metabolism Hepatic, via Cytochrome P450 3A4 Hepatic—important CYP2B6 and 2D6 involvement
Formula C17H13ClN4 C13H18ClNO

Wellbutrin vs. Xanax: tablet forms

Wellbutrin tablets are issued in two different forms with the dosage imprint on them:

  • 75 mg – yellow round pills
  • 100 mg – deep red round-shaped tablets

Xanax is available in four forms of different strengths:

  • 25 mg – white round pills
  • 5 mg – orange footballers
  • 1 mg – purple ellipses
  • 2 mg – white long capsule-shaped tablets

Dosing management

The physician is responsible for the dose management and the response control to the difference between Xanax and Wellbutrin.

Xanax

Wellbutrin

Alprazolam has to be taken three times a day at the amount of 0.25-0.5 mg. The best result can be achieved by applying the smallest effective dosage. The initial dose is to be increased every 3-4 days according to the patient’s needs and reactions. The maximum dose is 6 mg for anxiety treatment and 10 mg for panic attacks cure. Elderly patients have to take considerably smaller amounts of Xanax than adults.

Initially, Wellbutrin should be applied twice a day 100 mg each time. In the next 3 days, the dose can be raised up to 300 mg a day, divided between 3 intakes. The limit amount of Bupropion, which is 450 mg per day, should be prescribed in case the patient shows no improvement after several weeks of treating with 300mg.

Contraindications and Precautions

Wellbutrin (Bupropion) is contraindicated in the following cases:

  1. seizure
  2. abrupt alcohol consumption cutting
  3. eating disorder
  4. glaucoma
  5. epilepsy

Under no circumstances should Xanax (Alprazolam) be applied if the patient is having one of these diseases:

  • alcohol and drug dependence
  • suicidal attempts
  • narrow-angle glaucoma
  • severe kidney or liver disease

Pregnancy and breastfeeding

The difference between Xanax and Wellbutrin is that Xanax should not be prescribed to pregnant women. Wellbutrin, on the other hand, can be applied, if the potential benefit for the pregnant women is outweighing the risk for the fetus.

Alprazolam and Bupropion penetrate into breast milk, which might have a dangerous impact on the baby. For this reason, these drugs are not recommended during breastfeeding time.

Side Effects

Adverse reactions to Xanax should not bother the patient during the first week of treatment. This include:

  1. ataxia
  2. dizziness
  3. dry mouth
  4. light-headedness
  5. fatigue

Wellbutrin causes the following side effects:

  • epileptic seizures
  • nausea
  • weight loss
  • migraine
  • weakness
  • confusion

If you experience any of the effects, mentioned above, you should report this to your healthcare supervisor.

Drug interactions

Do not take Xanax with other benzodiazepines, including itraconazole and ketoconazole. Wellbutrin should not be applied with sedative medications, like Solfoton, Nembutal, Valium and Secona. It also has dangerous interactions with all types of MAO inhibitors.

Can you mix Xanax and Wellbutrin?

Mixing Wellbutrin and Xanax would most likely increase the sedative and relaxation effect. Adverse reactions are more likely to occur and become more intense if you combine these medications. Consider the possible hazard before taking Xanax with Wellbutrin.

Xanax vs. Hydroxyzine: market price

The pricing policy for these drugs is quite similar. Wellbutrin pills cost on average $1.81 per pill. The generic version is twice as cheap as the original. As for Xanax, the average tablet price is $1.95 with the possibility of getting a generic pill for less than $0.5.

Dr. Andrew J. Olson

Author: Dr. Andrew J. Olson

Dr. Andrew J. Olson is a PHD in psychiatry. He is also a psychiatrist consultant at the Royal Berkshire NHS Foundation Trust. He also serves as a Clinical Director of the Department of Psychiatry, at Royal Marsden Hospital, in London, UK.


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The variety of antidepressants in the drug stores is impressing. The demand for this medicine is increasing nearly 25% every year. Depression has different stages of severity and each of them requires a special treatment. Modern medications are extremely effective and diverse that allows choosing the best treatment for everyone. Xanax and Wellbutrin are well-known brands that can be found in every fifth prescription in the United States of America. Is Wellbutrin like Xanax? How are they different from each other? Can you take Xanax with Wellbutrin? What is the best antidepressant? To answer these and other questions, it is…
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